Coumarins and derivatives
Cayman Chemical 3-Cyno-7-ethoxycoumarIn 50mg
A PAI-1 inhibitor (IC50 6.95 UM) inhibits formation of a complex consisting of tPA PAI-1 and GFP on VECsin vitro prolonging the time that tPA is retained on VECs decreases blood clot weight in a rat model of arteriovenous shunt thrombosis when used at doses of 10 and 50 mg/kg increases the time to primary occlusion in a ferric chloride-treated carotid artery thrombosis model in rats when used at doses of 1 and 3 mg/kg increases the time to primary occlusion in a cynomolgus monkey model of photochemical-induced arterial thrombosis when used at a dose of 10 mg/kg does not affect platelet activity activated partial thromboplastin time prothrombin time or prolong bleeding time
Cayman Chemical 7-AzIdo-4-methylcoumarIn 5mg
An esterified form of 5-oxoETE an agonist of OXER1 (EC50 1 54 UM) that has a higher maximal response than 5-oxoETE in aBarrestin assay
TARGETMOL CHEMICALS INC 5-Geranoxy-7-methoxycoumarin
Also available in 1 mL, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. 5-Geranoxy-7-methoxycoumarin shows antifungal activity. Purity 99.99%
TARGETMOL CHEMICALS INC 3-Aminocoumarin 50MG
Also available in 5 mg, 10 mg, 25 mg, 100 mg, 200 mg and bulk. Please contact Fisher for quotes. 3-Aminocoumarin (3-aminochromen-2-one) is the key intermediate for the metal complexes. Purity 99.54%
Cayman Chemical 7-AmIno-4-methylcoumarIn 250mg
An ATR inhibitor inhibits proliferation in a panel of human tumor cell lines (mean IC50 78 nM) halts tumor growth in ovarian and colorectal mouse xenograft models and induces complete tumor remission in mantle cell lymphoma mouse xenograft models exhibits synergistic anti-tumor activity with radium-223 in a mouse xenograft model of castration-resistant prostate cancer bone metastases
Cayman Chemical 7-AmIno-4-methylcoumarIn 500mg
An ATR inhibitor inhibits proliferation in a panel of human tumor cell lines (mean IC50 78 nM) halts tumor growth in ovarian and colorectal mouse xenograft models and induces complete tumor remission in mantle cell lymphoma mouse xenograft models exhibits synergistic anti-tumor activity with radium-223 in a mouse xenograft model of castration-resistant prostate cancer bone metastases
